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The main contraindication (a specific situation in which you shouldnt use it because it may be harmful) for methylene blue is having a glucose-6-phosphate dehydrogenase (G6PD) deficiency

Do this instead: Start with 1/3 to 1/2 your normal portion

Mischley L

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Some clients also combine their injections with light meals, as carbohydrate intake can further enhance L-Carnitines uptake into muscle tissue through insulin activation, but this is less crucial with the injectable form